We are still learning about the long-term effects of COVID-19 on the brain. What are the mental health effects of COVID-19? Constant worries now keep you from sleeping at night. But most troubling for you is a feeling of dread, a nervousness so severe you can feel your heart pounding. The fatigue you experience makes moving from the bed to the kitchen feel like an accomplishment. In addition to constant headaches, you find yourself struggling with seemingly easy tasks. However, even though you no longer struggle to breathe, and your oxygen levels have returned to normal, something doesn’t feel right. Recommendations may vary depending on your community, whether you have underlying illnesses, and whether you’ve been vaccinated.ĭoctors told you that your COVID-19 virus infection cleared months ago. Please check the CDC web site for current information or talk to your doctor. Journal of Sleep Research, e13929.By: Stephanie Collier, MD, MPH, ContributorĮditor’s note: As information about COVID-19 continues to evolve, advice about protective measures changes. The relationship between mental health, sleep quality and the immunogenicity of COVID-19 vaccinations. Wagenhäuser, I., Reusch, J., Gabel, A., Mees, J., Nyawale, H., Frey, A., Lâm, T.-T., Schubert-Unkmeir, A., Dölken, L., Kurzai, O., Frantz, S., Petri, N., Krone, M., & Krone, L."Mental health, sleep, and immune function are interlinked, and it is of great clinical relevance to clarify if individuals with psychiatric conditions or poor sleepers are at risk of an insufficient response to COVID-19 booster vaccinations or if booster vaccinations might cause a sustained deterioration of sleep quality," investigators wrote. Overall, investigators found these results indicated that COVID-19 vaccinations are unlikely to be a precipitating factor for insomnia or have a lasting negative effect on sleep patterns. In addition, 154 participants underwent the fourth COVID-19 vaccination, and their data was collected before and 14 days after the booster vaccination.Īmong those who received the fourth COVID-19 vaccination, the data revealed no significant difference in antibody titers at baseline ( P = 0.59, Mann-Whitney U-test) or 14 days after vaccination ( P = 0.48, Mann-Whitney U-test) between participants without psychiatric disorders and those with psychiatric disorders. Additionally, the COVID-19 vaccinations did not result in a sustained deterioration of self-reported sleep quality. In terms of sleep quality, the study found no significant association between sleep quality and the humoral immunogenicity of COVID-19 vaccinations. However, there was a notable trend towards a higher prevalence of psychiatric disorders among women ( P = 0.05, Fisher's exact test). Questionnaires and blood samples were collected before the third COVID-19 vaccination and at 14 days and 3 months after the third vaccination.Īmong the cohort of individuals receiving the third COVID-19 vaccination (n = 1082), 86.0% (921) reported no psychiatric disorders, while 14.0% (n = 161) reported at least 1 psychiatric disorder.Īnalyzing the data by specific psychiatric disorders, there was no statistically significant difference in terms of gender composition. The prospective CoVacSer study monitored mental health, sleep quality, and Anti-SARS-CoV-2-Spike IgG titers in a cohort of 1082 healthcare workers from September 2021-December 2022. The association between sleep loss and reduced vaccine immunogenicity was noted, also citing that immune responses can affect sleep patterns. The Relationship of Sleep, Mental Health and Immune ResponseĪccording to the study, the relationship between sleep, mental health, and the immune system has been acknowledged, with sleep playing a crucial role in modulating immune responses. Investigators led by Isabell Wagenhäuser, an MD student at the Infection Control and Antimicrobial Stewardship Unit, University Hospital Würzburg, sought to evaluate the influence of mental health and sleep quality on the immunogenicity of COVID-19 vaccinations and the impact of COVID-19 vaccinations on sleep quality. Influencing factors of vaccine efficacy and safety were illuminated that can inform healthcare professionals in making recommendations regarding COVID-19 booster vaccinations for individuals with mental health and sleep-related issues. The data expanded the understanding of the relationship between mental health, sleep quality, and COVID-19 vaccine response. New findings revealed healthcare workers with psychiatric disorders had slightly lower Anti-SARS-CoV-2-Spike IgG levels before their third COVID-19 vaccination.
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